Which inhibits COX-2 enzyme involved in inflammation?

Which inhibits COX-2 enzyme involved in inflammation?

• A. COX-2 Inhibitor
• B. DMARDs
• C. Decongestant
• D. Emetic

Answer: (A)

In inflammation, blocking the COX-2 enzyme lowers the production of inflammatory prostaglandins, which reduces swelling, pain, and fever. A drug class designed to do exactly this is the COX-2 inhibitor, which selectively targets COX-2 at sites of inflammation while aiming to spare COX-1, the enzyme involved in protecting the stomach lining. This selective action helps lessen inflammatory symptoms with fewer gastrointestinal side effects than non-selective NSAIDs, though there can be cardiovascular considerations with these drugs. DMARDs work by modifying the disease process itself, not by directly inhibiting COX-2. Decongestants relieve nasal congestion through vasoconstriction and do not target inflammatory prostaglandin synthesis. Emetics induce vomiting and have no role in COX-2 inhibition. Therefore, the choice that best fits the aim of inhibiting COX-2 is the COX-2 inhibitor.

In inflammation, blocking the COX-2 enzyme lowers the production of inflammatory prostaglandins, which reduces swelling, pain, and fever. A drug class designed to do exactly this is the COX-2 inhibitor, which selectively targets COX-2 at sites of inflammation while aiming to spare COX-1, the enzyme involved in protecting the stomach lining. This selective action helps lessen inflammatory symptoms with fewer gastrointestinal side effects than non-selective NSAIDs, though there can be cardiovascular considerations with these drugs.

DMARDs work by modifying the disease process itself, not by directly inhibiting COX-2. Decongestants relieve nasal congestion through vasoconstriction and do not target inflammatory prostaglandin synthesis. Emetics induce vomiting and have no role in COX-2 inhibition. Therefore, the choice that best fits the aim of inhibiting COX-2 is the COX-2 inhibitor.