Which drug class works by inhibiting bone resorption to prevent osteoporosis?

Which drug class works by inhibiting bone resorption to prevent osteoporosis?

• A. Bone resorption inhibitor
• B. Corticosteroid
• C. Antipsychotic
• D. Anti-infective

Answer: (A)

Osteoporosis prevention hinges on slowing bone loss by suppressing osteoclast activity. Drugs that inhibit bone resorption do just that—they reduce osteoclast-mediated breakdown of bone, lowering bone turnover and helping maintain or increase bone density to prevent fractures. This class includes agents like bisphosphonates and denosumab, which directly target the cells responsible for bone resorption. Corticosteroids, when used chronically, can promote osteoporosis by decreasing bone formation and increasing resorption, so they are not used to prevent osteoporosis. Antipsychotics and anti-infectives do not act on bone remodeling in a way that prevents osteoporosis.

Osteoporosis prevention hinges on slowing bone loss by suppressing osteoclast activity. Drugs that inhibit bone resorption do just that—they reduce osteoclast-mediated breakdown of bone, lowering bone turnover and helping maintain or increase bone density to prevent fractures. This class includes agents like bisphosphonates and denosumab, which directly target the cells responsible for bone resorption.

Corticosteroids, when used chronically, can promote osteoporosis by decreasing bone formation and increasing resorption, so they are not used to prevent osteoporosis. Antipsychotics and anti-infectives do not act on bone remodeling in a way that prevents osteoporosis.