Which drug class suppresses inflammation and modifies the normal immune response?

Which drug class suppresses inflammation and modifies the normal immune response?

• A. Corticosteroid
• B. Electrolyte replacement
• C. Anti-infective
• D. Bone resorption inhibitor

Answer: (A)

Corticosteroids are known for both anti-inflammatory and immunosuppressive effects. They enter cells and bind glucocorticoid receptors, leading to changes in gene expression that lower the production of inflammatory mediators. This includes inhibiting phospholipase A2, which reduces arachidonic acid-derived prostaglandins and leukotrienes, and decreasing the release of pro-inflammatory cytokines like IL-1, IL-6, and TNF-alpha. They also dampen immune cell activity and migration, resulting in a suppressed immune response. That combination of reducing inflammation and modulating the immune system is what makes corticosteroids the best fit for the description. Electrolyte replacement addresses mineral balance, not inflammation or immune function. Anti-infectives target pathogens but don’t inherently suppress the immune response as their defining action. Bone resorption inhibitors affect bone metabolism rather than inflammation or immunity.

Corticosteroids are known for both anti-inflammatory and immunosuppressive effects. They enter cells and bind glucocorticoid receptors, leading to changes in gene expression that lower the production of inflammatory mediators. This includes inhibiting phospholipase A2, which reduces arachidonic acid-derived prostaglandins and leukotrienes, and decreasing the release of pro-inflammatory cytokines like IL-1, IL-6, and TNF-alpha. They also dampen immune cell activity and migration, resulting in a suppressed immune response. That combination of reducing inflammation and modulating the immune system is what makes corticosteroids the best fit for the description.

Electrolyte replacement addresses mineral balance, not inflammation or immune function. Anti-infectives target pathogens but don’t inherently suppress the immune response as their defining action. Bone resorption inhibitors affect bone metabolism rather than inflammation or immunity.